Senior Scientist, Translational and Diagnostic Informatics JobCelgene Corporation - Summit, NJ
Nov 15, 2017
- n/a -
- n/a -
US - New Jersey - Summit
Email Job to a Friend
Save Job to Inbox
Translational Development at Celgene
Celgene Corporation, headquartered in Summit, New Jersey, is an integrated global biopharmaceutical company engaged in the discovery, development and commercialization of novel therapies for the treatment of cancer and inflammatory diseases. At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients. Investigational compounds are being studied for patients with hematological and solid tumor cancers, including multiple myeloma, myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), chronic lymphocyte leukemia (CLL), non-Hodgkin's lymphoma (NHL), pancreatic cancer and lung cancer.
Translational Development is a department within the Research and Development organization that facilitates the transition of drug candidates from drug discovery through early- and late-stage clinical development. Early-stage translational development activities enable rational determination of dose-schedule and responsive patient populations, based on deep understanding of drug mechanism of action. Late-stage translational development activities build upon the early work, additionally exploring mechanisms of resistance, rational drug combinations and product differentiation. The late-stage translational development function is responsible for the development of translational strategies to support the development, and maximize the potential, of Celgene therapies post-clinical proof-of-concept, including registrations and life-cycle management.
Dual reporting to Translational Development and Research Analytics, the candidate will be part of the late stage translational development group based in either Northern New Jersey or San Francisco bay area California.
We seek a talented, collaborative computational scientist to lead work on the analysis of high-dimensional tissue, cell and molecular profiling data. The successful applicant is expected to play a key scientific and strategic role leveraging innovative computational analysis strategies and rich patient data to empower data-driven decisions for development programs in Celgene’s clinical portfolio.
Scientific activities associated with this position range from provision of deep insight into therapeutic mechanisms of action for existing therapies and novel therapies in clinical development, identification and predictive leverage of patient phenotypes associated with therapeutic effect and outcome in key indications, and development of molecular biomarker hypotheses for implementation into clinical trials as potential diagnostic tests. Data will originate from a wide range of cellular and molecular profiling platforms, including transcriptomic, proteomic, genomic, functional and immunophenotypic assays.
The role offers the opportunity to directly impact the delivery of transformational therapies in key diseases of unmet medical need, particularly in lymphoid and myeloid diseases. Strong interest in the inter-disciplinary application of computational analysis methods to life sciences data is imperative.
Working in collaboration with computational, biological and clinical scientists across the Celgene Research and Development organization, responsibilities include but are not limited to:
•Active participation as a core team member in the Translational Development and Diagnostics Department and RIKU Research Analytics group.
•Participate in cross-functional disease teams in the identification of clinically-relevant patient segments by analysis of public and proprietary biomarker and clinical data.
•Guide development of molecular patient selection and biomarker hypotheses towards clinical diagnostics. Work closely with Translational Diagnostics scientists to develop molecular assay strategies.
•Prioritize across projects and take responsibility for delivery of research output to agreed objectives and timelines. Author scientific reports, with methods, results and conclusions presented in a publishable standard.
•Apply novel computational analysis and biological interpretation approaches to leverage internal, public and partner datasets and empower data-driven decisions across therapeutic programs.
•Multi-disciplinary collaboration to investigate compound and disease properties, influence decision making across the translational research and clinical development process, and feedback to inform early development of novel therapies.
•Data integration across assay platforms and knowledge transfer from pre-clinical experiments to clinical trials.
•Contribution to planning and execution of collaborative projects with leading academic and commercial research groups worldwide.
Background experience & complementary knowledge
•A Ph.D. in computational biology, bioinformatics, or related field from a recognized higher-education establishment. 2 years experience in pharma/biotech research environment preferable.
•Track record of peer-reviewed publications in top-tier scientific journals
•Experience in quality assessment, analysis, interpretation and visualization of terabyte-scale datasets, including high-throughput sequencing data
•Expertise in algorithmic implementation, statistical programming and data manipulation, using e.g. R/Bioconductor and contemporary, open-source bioinformatics tools and database structures. Preference given to candidates with a track record of developing portable algorithms that can be shared with peers
•Proven expertise in the development and / or implementation of algorithms to distill, analyze and interpret complex datasets, particularly those associated with pharmacogenomics and biomarker discovery
•Proven problem-solving skills, collaborative nature and adaptability across disciplines.
•Excellent verbal and written communication skills. Fluent verbal and written English language skills prerequisite.
Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.
Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S
United States-New Jersey-Summit
Research and Early Development
applySenior Scientist, Translational and Diagnostic Informatics Job Celgene Corporation - Summit, NJ, United States
Celgene is a multinational biopharmaceutical company committed to improving the lives of patients worldwide. At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients. Our mission as a company is to build a major global biopharmaceutical corporation while focusing on the discovery, the development, and the commercialization of products for the treatment of cancer and other severe, immune, inflammatory conditions. There are numerous clinical trials at major medical centers using compounds from Celgene. Investigational compounds are being studied for patients with incurable hematological and solid tumor cancers, including multiple myeloma, myelodysplastic syndromes, chronic lymphocyte leukemia (CLL), non-Hodgkin's lymphoma (NHL), glioblastoma, and ovarian, pancreatic and prostate cancer.
Jobs You Might Also Like
View More Jobs in Summit, NJ:
- View More Jobs in Summit, NJ
- More Senior Scientist Translational and Diagnostic Informatics Job Jobs in Summit, NJ
- More Celgene Corporation Jobs in Summit, NJ
View More Jobs in New Jersey:
- View More Jobs in New Jersey
- More Senior Scientist Translational and Diagnostic Informatics Job Jobs in New Jersey
- More Celgene Corporation Jobs in New Jersey